Can Immunity Impact Alzheimer’s Disease?
Evolutionary Selection of APOE 4 Encourages Increased Focus on Immunity in Alzheimer’s Disease By: Christopher J. Wheeler Abstract. Smith and Ashford present a compelling hypothesis on evolution of APOE alleles, namely that 4 prevalence is mediated by immune selection pressure against enteric pathogens. While the…
Amyloid hypotheses – From widely accepted to hotly debated
The past month has led way to what many in the Alzheimer’s field might consider a “seismic shift”. The controversy began when it was revealed that data underlying the most prominent theory of Alzheimer’s causation – the amyloid hypothesis – was potentially manipulated or even…
Functional recreation of age-related CD8 T cells in young mice identifies drivers of aging- and human-specific tissue pathology
Congrats to the whole T-Neuro team, and especially Chris Wheeler on our recent publication! This is a significant step forward in understanding how s specific immune change leads to disorders of aging throughout the body. The work introduces a unique research tool to examine how…